作者: Riera Marta Carrascal , Pou Silvia Fonquerna , Juan Bernat Vidal , Martinez Lorena Taboada , Izquierdo Nuria Aguilar
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摘要: The present invention relates to an oxadiazole derivative of formula (I)1 or a pharmaceutically acceptable salt N-oxide thereof: wherein, R 1 represents hydrogen atom, C 1-2 alkyl group 3-4 cycloalkyl-C group, both 2 and 3 represent group; atom b , cycloalkyl carboxy carbamoyl -CF c linear branched 2.5 substituted with one substituent selected from hydroxy triazolyl -P(O)(OH) -(CH )( )-C(O)OR' -NR'R" NR'R" )-NHC(O)R" ) (2-4) NH-(CH (1-3) -O-(CH (2-3) wherein: R' R" atom; 5-6 5- 6-membered saturated heterocyclic ring containing nitrogen carboxy(C alkyl) optionally by more substituents halogen atoms, groups, methyl amino groups groups; together the which they are attached form (a) 4 6 membered unsaturated contains, as heteroatom, N and, optionally, further is oxy (b) 5 heteroaryl atoms group.