Curative treatment of Stage I non–small-cell lung cancer with carbon ion beams using a hypofractionated regimen

摘要: Purpose: A phase I/II study on carbon ion radiotherapy for Stage I non–small-cell lung cancer (NSCLC) was first conducted between 1994 and 1999 determined the optimal dose. Second, a Phase II using dose performed. The purpose of present to clarify local control 5-year survival rates. Methods Materials: Between April December 2000, 50 patients with 51 primary lesions were treated. Using fixed 72 GyE in nine fractions over 3 weeks, tumors irradiated beams alone. average age 74.5 years. Thirty-three (66%) these medically inoperable. Local by Kaplan-Meier method data statistically processed log–rank test. Results: All observed minimum 5 years or until death median follow-up time 59.2 months (range, 6.0–83.0 months). rate all 94.7%. patients’ cause-specific 75.7% (IA: 89.4; IB: 55.1), overall 50.0% 55.2; 42.9). No toxic reactions greater than Grade detected. Conclusions: Carbon radiotherapy, new treatment modality superior benefits terms quality life activity daily living, has been proven as valid alternative surgery NSCLC offer particular benefits, especially elderly inoperable patients.