Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence

摘要: The attention of drug-dependent persons tends to be captured by stimuli associated with drug consumption. This involuntary cognitive process is considered as attentional bias (AB). AB has been hypothesized have causal effects on abuse and relapse, but its underlying neural mechanisms are still unclear. study investigated the basis in abstinent heroin addicts (AHAs), combining event-related potential (ERP) analysis source localization techniques. Electroencephalography data were collected 21 24 age- gender-matched healthy controls (HCs) during a dot-probe task. In task, pair drug-related image neutral was presented randomly left right side cross fixation, followed dot probe replacing one images. Behaviorally, AHAs had shorter reaction times (RTs) for congruent condition compared incongruent condition, whereas this not case HCs. finding demonstrated presence towards cues AHAs. Furthermore, image-evoked ERPs significant P1 latency HCs, well larger N1, N2, P2 amplitude, suggesting that might capture early overall require more resources target-related P3 significantly lower amplitude than Moreover, ERP components revealed increased activity HCs dorsal posterior cingulate cortex (dPCC), superior parietal lobule inferior frontal gyrus (IFG) image-elicited responses, decreased occipital medial lobes target-elicited responses. Overall, results our confirmed may exhibit contexts, suggested related an abnormal activity, both late processing stages.