Effects of tetrahydrocannabinol on glucose uptake in the rat brain.
作者： S. Maus , N. Bausbacher , K. Krauter , V. Weyer-Elberich , B. Lutz
DOI: 10.1016/J.NEUROPHARM.2017.02.011
关键词:
摘要: Δ9-Tetrahydrocannabinol (THC) is the psychoactive component of plant Cannabis sativa and acts as a partial agonist at cannabinoid type 1 2 receptors in brain. The goal this study was to assess effect THC on cerebral glucose uptake rat 21 male Sprague Dawley rats (12-13 w) were examined received five different doses ranging from 0.01 1 mg/kg. For data acquisition Focus 120 small animal PET scanner used 24.1-28.0 MBq [18F]-fluoro-2-deoxy-d-glucose injected. acquired for 70 min arterial blood samples collected throughout scan. THC, THC-OH THC-COOH determined 55 min p.i. Nine volumes interest defined, calculated each brain region. Low levels 10 ng/ml (injected dose: ≥ 0.05 mg/kg) coincided with decreased (-2 to -22 %), especially cerebellar cortex (p = 0.008). effective concentration region estimated 2.4 ng/ml. This showed that stimulation CB1 by affects brain, whereby regionally dependent dose - an may be relevance behavioural studies.
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