Antioxidant, Antimutagenic and Cytotoxic Properties of Essential Oil from Corchorus olitorius L. Flowers and Leaf

摘要: Background: This present research highlight the phytochemical profile, antioxidant, antimicrobial, antimutagenic and antiproliferative activities of an essential oil extracted from Corchorus olitorius L. flowers leaf (COFL), aromatic plant widely distributed in Tunisia used as a traditional food plant. Results: Gas chromatography/ mass spectrometry was to determine composition COFL (COFL-EO). Forty-three components were identified main compounds benzaldehyde (56%), methyl 4-methoxysalicylate (6.55%) carvacrol (4.75%). The COFL-EO also found possess antioxidant activities, evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical method β-carotene bleaching assay. antibacterial showed good growth inhibition compared positive controls. diameter zones reached maximum 16.7 ± 0.1 mm when tested against Salmonella typhimurium using just 6 mg extract. On other hand, activity assessed Ames Salmonella/microsome mutagenicity test COLF-EO exhibited high effects at 0.125, 0.0125 0.00125 mg/plate. Antiproliferative this four mammalian cells lines significantly stronger Hela cell line (IC 50 =4 0.98 µg/mL). Conclusion: Overall, results presented here suggest that is potential new source active ingredients for pharmaceutical industry.