PENGARUH PEMBERIAN DMSO SEBAGAI PELARUT BAHAN UJI PADA UJI AKTIVITAS ANTIPLASMODIUM INVIVO TERHADAP PERTUMBUHAN Plasmodium berghei PADA MENCIT

摘要: The material tests in the form of extract, fraction or even compound are sometimes difficult to dissolve water. In vivo activity test antiplasmodium on mouse, must be dissolved, so it can given orally other way tests. One solvents normally used is dimethyl sulfoxide (DMSO). DMSO besides as solvent a chemical that has low toxicity and effect antiinflammation analgetic. this research, been Plasmodium berghei model. To see whether , will further tested if growth P. . method research was four days supresive Swiss mice were grouped into 6 group based dose level negative control. infected with much 1 x 10 7 intraperitoneally. 2 hours after infection process, oral while control not. for 4 continousely. On fifth day, blood taken from tail smear prepared. giemsa check under microcope. parasitemia values each compared analyzed statistically one line ANOVA difference. statistic data revealed there no significant average value different variety level. It concluded up 20% did not affect during antiplasmodium. Keywords : DMSO, organic solvent, berghei,