Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea
作者： Aun Chea , Sotheara Hout , Christophe Long , Laurence Marcourt , Robert Faure
DOI: 10.1248/CPB.54.1437
关键词:
摘要: Two new sesquiterpene lactones, vernolides C and D as well six known ones were isolated from the dichloromethane fraction of an aqueous extract Vernonia cinerea. Their structures elucidated by spectroscopic methods. Among three them described in this plant for first time. In vitro antiplasmodial evaluation showed that major compounds 1, 7 8 active against chloroquine resistant Plasmodium falciparum strain (W2) with IC50 3.9, 3.7 3.5 μM, respectively.
sci-hub.se 参考文章(10)
A.M. Abeysekera, K.T.D. de Silva, S.R.P. de Silva, V.D.P. Sirimanne, R.P. Labadie, A.J.J. van den Berg, W. Vander Sluis, Inhibition of chemiluminescence generated by zymosan-activated polymorphonuclear leucocytes by phenolic constituents of Vernonia cinerea Fitoterapia. ,vol. 70, pp. 317- 319 ,(1999) , 10.1016/S0367-326X(99)00052-0
Ferdinand Bohlmann, Pradip K. Mahanta, Lakshmi N. Dutta, Weitere hirsutinolide aus Vernonia-arten☆ Phytochemistry. ,vol. 18, pp. 289- 291 ,(1979) , 10.1016/0031-9422(79)80073-4
Marcelo J.P Ferreira, Francimeiry C Oliveira, Sandra A.V Alvarenga, Patrı́cia A.T Macari, Gilberto V Rodrigues, Vicente P Emerenciano, Automatic identification by 13C NMR of substituent groups bonded in natural product skeletons. Computational Biology and Chemistry. ,vol. 26, pp. 601- 632 ,(2002) , 10.1016/S0097-8485(02)00029-3
Ferdinand Bohlmann, Gerhard Brindöpke, Ramesh C. Rastogi, A new type of germacranolide from Vernonia species Phytochemistry. ,vol. 17, pp. 475- 482 ,(1978) , 10.1016/S0031-9422(00)89342-5
Sotheara Hout, Aun Chea, Sok-Siya Bun, Riad Elias, Monique Gasquet, Pierre Timon-David, Guy Balansard, Nadine Azas, Screening of selected indigenous plants of Cambodia for antiplasmodial activity. Journal of Ethnopharmacology. ,vol. 107, pp. 12- 18 ,(2006) , 10.1016/J.JEP.2006.01.028
Susana Borkosky, Alicia Bardón, César AN Catalán, Jesús G Díaz, Werner Herz, None, GLAUCOLIDES, HIRSUTINOLIDES AND OTHER SESQUITERPENE LACTONES FROM VERNONANTHURA PINGUIS Phytochemistry. ,vol. 44, pp. 465- 470 ,(1997) , 10.1016/S0031-9422(96)00481-5
A. Schuster, J.D. Msonthi, S. Keeley, J. Jakupovic, S. Banerjee, V. Castro, F. Bohlmann, Poskeanolide, a seco-germacranolide and other sesquiterpene lactones from Vernonia species Phytochemistry. ,vol. 25, pp. 1359- 1364 ,(1986) , 10.1016/S0031-9422(00)81290-X
Ferdinand Bohlmann, Christa Zdero, Robert M. King, Harold Robinson, Germacranolides from Stilpnopappus species Phytochemistry. ,vol. 21, pp. 1045- 1048 ,(1982) , 10.1016/S0031-9422(00)82414-0
E.O Iwalewa, O.J Iwalewa, J.O Adeboye, Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf Journal of Ethnopharmacology. ,vol. 86, pp. 229- 234 ,(2003) , 10.1016/S0378-8741(03)00081-3
Yao-Haur Kuo, Yu-Jen Kuo, Ang-Su Yu, Ming-Der Wu, Chi-Wi Ong, Li-Ming Yang Kuo, Jo-Ti Huang, Chieh-Fu Chen, Shyh-Yuan Li, Two Novel Sesquiterpene Lactones, Cytotoxic Vernolide-A and -B, from Vernonia cinerea Chemical & Pharmaceutical Bulletin. ,vol. 51, pp. 425- 426 ,(2003) , 10.1248/CPB.51.425