Modulation of cytotoxic T lymphocyte, natural killer cell, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by Vernonia cinerea L. and vernolide-A in BALB/c mice via enhanced production of cytokines IL-2 and IFN-γ.
作者： Poyil Pratheeshkumar , Girija Kuttan
DOI: 10.3109/08923973.2011.574703
关键词: Cytotoxicity 、 BALB/c 、 Cytotoxic T cell 、 Natural killer cell 、 Immunology 、 Molecular biology 、 Interferon 、 Interleukin 、 Immune system 、 Antibody-dependent cell-mediated cytotoxicity 、 Biology
摘要: Effect of Vernonia cinerea L. and vernolide-A on cell-mediated immune (CMI) response was studied in normal as well tumor-bearing BALB/c mice. Administration V. significantly enhanced natural killer (NK) cell activity both animals, the observed earlier than control animals. Antibody-dependent cellular cytotoxicity (ADCC) antibody-dependent complement-mediated (ACC) were also animals after administration compared with untreated Extract showed a significant increase cytotoxic T lymphocyte (CTL) production vivo vitro models. The level cytokines such interleukin (IL)-2 interferon (IFN)-γ by treatment This study demonstrated tha...
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