Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies.

摘要: Background: Volumetric atrophy and microstructural alterations in diffusion tensor imaging (DTI) measures of the hippocampus have been reported people with Alzheimer's disease (AD) mild cognitive impairment (MCI). However, no study to date has jointly investigated concomitant volumetric changes dementia Lewy bodies (DLB). Methods: A total 84 subjects (23 MCI, 17 DLB, 14 AD, 30 healthy controls) were recruited for a multi-modal (3T MRI DTI) that included neuropsychological evaluation. Freesurfer was used segment delineate its subfields. The hippocampal segmentations co-registered mean diffusivity (MD) fractional anisotropy (FA) maps obtained from DTI images. Results: Both AD MCI groups showed significantly smaller volumes compared DLB controls, predominantly CA1 subiculum Compared MD elevated but not MCI. characterized by both preservation hippocampus. In higher associated greater region. Hippocampal volume stronger predictor memory scores within group. Conclusions: Through integration, we report novel evidence is macrostructural preservation. Contrary recent suggestions, our findings do support view measurements are superior characterizing group differences, particularly between controls.