Treatment of male fertility disturbances. Current concepts
作者： W.-B. Schill , M. Michalopoulos
DOI: 10.2165/00003495-198428030-00003
关键词:
摘要: Medical therapy of male infertility aims to improve or normalise the fertility status a subfertile patient. However, this can be frustrating task due limited knowledge about pathophysiology reproductive functions, and fact that pharmacological is mainly empirical less often specific. Nevertheless, spectrum treatment approaches has increased within last decade comprises hormonal non-hormonal compounds. Hormonal performed with antioestrogens (clomiphene, tamoxifen), gonadotrophin- releasing hormone (GnRH), prolactin inhibitors (bromocriptine), gonadotrophins (hMG, hCG), androgens (testosterone, mesterolone), testosterone aromatase (testolactone). Tissue hormone- proteases (kallikrein) also applied, liberating kinins as mediator substances different effects at cellular level Non-hormonal includes improvement testicular microcirculation by oxpentifylline, antimicrobial anti-inflammatory agents, drugs allow emission ejaculation, psychotropic antispasmodic diminish functional disturbances induced emotional stress.
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