The use of microdialysis in pharmacokinetics and pharmacodynamics
作者： Lars Ståhle
DOI: 10.1016/B978-0-444-81194-3.50012-5
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摘要: Publisher Summary This chapter highlights the use of microdialysis in pharmacokinetics and pharmacodynamics. The also discusses validity various methods to estimate interstitial free concentration (IFC) by application relate vivo effects IFC organ which drug exerts effect. study distribution fluid different organs. time-course phase can be studied much better detail than with any other method. possibility should considerable interest drugs abuse as rate brain is believed a variable importance. Microdialysis may become an important tool particular organs, such brain, vitreous body, placenta, fetus.
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