Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice.
作者： Monique E. Verhaegen , Doris Mangelberger , Paul W. Harms , Markus Eberl , Dawn M. Wilbert
DOI: 10.1158/0008-5472.CAN-17-0035
关键词:
摘要: Merkel cell carcinoma (MCC) tumor cells express several markers detected in normal cells, a nonproliferative population of neuroendocrine that arise from epidermis. MCCs frequently contain polyomavirus (MCPyV) DNA and viral transforming antigens, sT tLT, but the role these putative oncogenes MCC development, this tumor's origin, are unknown. Using panel preterm transgenic mice, we show epidermis-targeted coexpression fate-determinant atonal bHLH transcription factor 1 (ATOH1) leads to development widespread cellular aggregates, with histology marker expression mimicking human intraepidermal MCC. The MCC-like phenotype was dependent on FBXW7-binding domain sT, not sT-PP2A binding domain. Coexpression MCPyV tLT did appreciably alter driven by either or combined ATOH1. when coexpressed ATOH1, is thus sufficient initiate epidermis-derived tumors mice. Cancer Res; 77(12); 3151-7. ©2017 AACR.
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sci-hub.se 参考文章(22)
Huda Y. Zoghbi, Andrew L. Abney, Amy W. Helms, Jane E. Johnson, Nissim Ben-Arie, Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development. ,vol. 127, pp. 1185- 1196 ,(2000) , 10.1242/DEV.127.6.1185
Ingrid Moll, Wolfgang Zieger, Monika Schmelz, Proliferative merkel cells were not detected in human skin Archives of Dermatological Research. ,vol. 288, pp. 184- 187 ,(1996) , 10.1007/BF02505222
Roland Houben, Christian Adam, Anne Baeurle, Sonja Hesbacher, Johannes Grimm, Sabrina Angermeyer, Katharina Henzel, Stefanie Hauser, Roland Elling, Eva-B. Bröcker, Stefan Gaubatz, Jürgen C. Becker, David Schrama, An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. International Journal of Cancer. ,vol. 130, pp. 847- 856 ,(2012) , 10.1002/IJC.26076
C. N. Perdigoto, E. S. Bardot, V. J. Valdes, F. J. Santoriello, E. Ezhkova, Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network Development. ,vol. 141, pp. 4690- 4696 ,(2014) , 10.1242/DEV.112169
Justin A Wendzicki, Patrick S Moore, Yuan Chang, Large T and small T antigens of Merkel cell polyomavirus Current Opinion in Virology. ,vol. 11, pp. 38- 43 ,(2015) , 10.1016/J.COVIRO.2015.01.009
Angel Ramírez, Ana Bravo, José L. Jorcano, Miguel Vidal, Sequences 5′ of the bovine keratin 5 gene direct tissue‐ and cell‐type‐specific expression of a lacZ gene in the adult and during development Differentiation. ,vol. 58, pp. 53- 64 ,(1994) , 10.1046/J.1432-0436.1994.5810053.X
Monique E. Verhaegen, Doris Mangelberger, Paul W. Harms, Tracy D. Vozheiko, Jack W. Weick, Dawn M. Wilbert, Thomas L. Saunders, Alexandre N. Ermilov, Christopher K. Bichakjian, Timothy M. Johnson, Michael J. Imperiale, Andrzej A. Dlugosz, Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice. Journal of Investigative Dermatology. ,vol. 135, pp. 1415- 1424 ,(2015) , 10.1038/JID.2014.446
James A. DeCaprio, Robert L. Garcea, A cornucopia of human polyomaviruses. Nature Reviews Microbiology. ,vol. 11, pp. 264- 276 ,(2013) , 10.1038/NRMICRO2992
Piotr Czapiewski, Wojciech Biernat, Merkel cell carcinoma - recent advances in the biology, diagnostics and treatment. The International Journal of Biochemistry & Cell Biology. ,vol. 53, pp. 536- 546 ,(2014) , 10.1016/J.BIOCEL.2014.04.023
Kristin M. Morrison, George R. Miesegaes, Ellen A. Lumpkin, Stephen M. Maricich, Mammalian Merkel cells are descended from the epidermal lineage Developmental Biology. ,vol. 336, pp. 76- 83 ,(2009) , 10.1016/J.YDBIO.2009.09.032