Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma

Mark Sausen, Jillian Phallen, Vilmos Adleff, Siân Jones, Rebecca J Leary, Michael T Barrett, Valsamo Anagnostou, Sonya Parpart-Li, Derek Murphy, Qing Kay Li, Carolyn A Hruban, Rob Scharpf, James R White, Peter J O’Dwyer, Peter J Allen, James R Eshleman, Craig B Thompson, David S Klimstra, David C Linehan, Anirban Maitra, Ralph H Hruban, Luis A Diaz Jr, Daniel D Von Hoff, Julia S Johansen, Jeffrey A Drebin, Victor E Velculescu, None, Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients Nature Communications. ,vol. 6, pp. 7686- 7686 ,(2015) , 10.1038/NCOMMS8686

Hideaki Kinugasa, Kazuhiro Nouso, Koji Miyahara, Yuki Morimoto, Chihiro Dohi, Koichiro Tsutsumi, Hironari Kato, Takehiro Matsubara, Hiroyuki Okada, Kazuhide Yamamoto, Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer. Cancer. ,vol. 121, pp. 2271- 2280 ,(2015) , 10.1002/CNCR.29364

Lola Rahib, Benjamin D. Smith, Rhonda Aizenberg, Allison B. Rosenzweig, Julie M. Fleshman, Lynn M. Matrisian, Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States Cancer Research. ,vol. 74, pp. 2913- 2921 ,(2014) , 10.1158/0008-5472.CAN-14-0155

Nicola Waddell, Marina Pajic, Ann-Marie Patch, David K Chang, Karin S Kassahn, Peter Bailey, Amber L Johns, David Miller, Katia Nones, Kelly Quek, Michael CJ Quinn, Alan J Robertson, Muhammad ZH Fadlullah, Tim JC Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, Shivangi Wani, Peter J Wilson, Emma Markham, Nicole Cloonan, Matthew J Anderson, J Lynn Fink, Oliver Holmes, Stephen H Kazakoff, Conrad Leonard, Felicity Newell, Barsha Poudel, Sarah Song, Darrin Taylor, Nick Waddell, Scott Wood, Qinying Xu, Jianmin Wu, Mark Pinese, Mark J Cowley, Hong C Lee, Marc D Jones, Adnan M Nagrial, Jeremy Humphris, Lorraine A Chantrill, Venessa Chin, Angela M Steinmann, Amanda Mawson, Emily S Humphrey, Emily K Colvin, Angela Chou, Christopher J Scarlett, Andreia V Pinho, Marc Giry-Laterriere, Ilse Rooman, Jaswinder S Samra, James G Kench, Jessica A Pettitt, Neil D Merrett, Christopher Toon, Krishna Epari, Nam Q Nguyen, Andrew Barbour, Nikolajs Zeps, Nigel B Jamieson, Janet S Graham, Simone P Niclou, Rolf Bjerkvig, Robert Grützmann, Daniela Aust, Ralph H Hruban, Anirban Maitra, Christine A Iacobuzio-Donahue, Christopher L Wolfgang, Richard A Morgan, Rita T Lawlor, Vincenzo Corbo, Claudio Bassi, Massimo Falconi, Giuseppe Zamboni, Giampaolo Tortora, Margaret A Tempero, Royal North Shore Hospital Samra Jaswinder S. 39 Gill Anthony J. 39 Pavlakis Nick 39 Guminski Alex 39 Toon Christopher 39, Bankstown Hospital Asghari Ray 40 Merrett Neil D. 40 Pavey Darren 40 Das Amitabha 40, Liverpool Hospital Cosman Peter H. 41 Ismail Kasim 41 O’Connnor Chelsie 41, Westmead Hospital Lam Duncan McLeod Vincent W. 42 42 Pleass Henry C. 42 Richardson Arthur 42 James Virginia 42, Royal Prince Alfred Hospital Kench James G. 43 Cooper Caroline L. 43 Joseph David 43 Sandroussi Charbel 43 Crawford Michael 43 Gallagher James 43, Fremantle Hospital Texler Michael 44 Forest Cindy 44 Laycock Andrew 44 Epari Krishna P. 44 Ballal Mo 44 Fletcher David R. 44 Mukhedkar Sanjay 44, Sir Charles Gairdner Hospital Spry Nigel A. 45 DeBoer Bastiaan 45 Chai Ming 45, St John of God Healthcare Zeps Nikolajs 46 Beilin Maria 46 Feeney Kynan 46, Royal Adelaide Hospital Nguyen Nan Q. 47 Ruszkiewicz Andrew R. 47 Worthley Chris 47 Tan Chuan P. 47 Debrencini Tamara 47, Flinders Medical Centre Chen John 48 Brooke-Smith Mark E. 48 Papangelis Virginia 48, Greenslopes Private Hospital Tang Henry 49 Barbour Andrew P. 49, Envoi Pathology Clouston Andrew D. 50 Martin Patrick 50, Princess Alexandria Hospital O’Rourke Thomas J. 51 Chiang Amy 51 Fawcett Jonathan W. 51 Slater Kellee 51 Yeung Shinn 51 Hatzifotis Michael 51 Hodgkinson Peter 51, Austin Hospital Christophi Christopher 52 Nikfarjam Mehrdad 52 Mountain Angela 52, Victorian Cancer Biobank, Johns Hopkins Medical Institutes Eshleman James R. 54 Hruban Ralph H. 54 Maitra Anirban 54 Iacobuzio-Donahue Christine A. 54 Schulick Richard D. 54 Wolfgang Christopher L. 54 Morgan Richard A 54 Hodgin Mary 54, ARC-Net Centre for Applied Research on Cancer Scarpa Aldo 55 Lawlor Rita T. 55 Beghelli Stefania 55 Corbo Vincenzo 55 Scardoni Maria 55 Bassi Claudio 55, University of California, San Francisco Tempero Margaret A. 56, University of Glasgow Biankin Andrew V. 36 37 57 Grimmond Sean M. 37 38 Chang David K. 36 37 57 Musgrove Elizabeth A. 37 Jones Marc D. 36 37 Nourse Craig 37 38 Jamieson Nigel B. 37 57 Graham Janet S. 37 57, Greater Glasgow & Clyde National Health Service Biankin Andrew V. 36 37 57 Chang David K. 36 37 57 Jamieson Nigel B. 37 57 Graham Janet S. 37 57 Oien Karen 37 57 Hair Jane 57, None, Whole genomes redefine the mutational landscape of pancreatic cancer. Nature. ,vol. 518, pp. 495- 501 ,(2015) , 10.1038/NATURE14169

J. Martin Bland, Douglas G. Altman, Statistical methods for assessing agreement between two methods of clinical measurement International Journal of Nursing Studies. ,vol. 47, pp. 931- 936 ,(2010) , 10.1016/J.IJNURSTU.2009.10.001

Cristina R. Ferrone, Giovanni Marchegiani, Theodore S. Hong, David P. Ryan, Vikram Deshpande, Erin I. McDonnell, Francesco Sabbatino, Daniela Dias Santos, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, Jason E. Faris, Lipika Goyal, Eunice L. Kwak, Janet E. Murphy, David T. Ting, Jennifer Y. Wo, Andrew X. Zhu, Andrew L. Warshaw, Keith D. Lillemoe, Carlos Fernández-del Castillo, Radiological and Surgical Implications of Neoadjuvant Treatment With FOLFIRINOX for Locally Advanced and Borderline Resectable Pancreatic Cancer Annals of Surgery. ,vol. 261, pp. 12- 17 ,(2015) , 10.1097/SLA.0000000000000867

J. Martin Bland, DouglasG. Altman, Statistical methods for assessing agreement between two methods of clinical measurement. The Lancet. ,vol. 327, pp. 307- 310 ,(1986) , 10.1016/S0140-6736(86)90837-8

H. Chen, H. Tu, Z.Q. Meng, Z. Chen, P. Wang, L.M. Liu, K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer Ejso. ,vol. 36, pp. 657- 662 ,(2010) , 10.1016/J.EJSO.2010.05.014

Agnieszka K. Witkiewicz, Elizabeth A. McMillan, Uthra Balaji, GuemHee Baek, Wan-Chi Lin, John Mansour, Mehri Mollaee, Kay-Uwe Wagner, Prasad Koduru, Adam Yopp, Michael A. Choti, Charles J. Yeo, Peter McCue, Michael A. White, Erik S. Knudsen, Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets Nature Communications. ,vol. 6, pp. 6744- 6744 ,(2015) , 10.1038/NCOMMS7744

A D Nygaard, P C Holdgaard, K-L G Spindler, N Pallisgaard, A Jakobsen, The correlation between cell-free DNA and tumour burden was estimated by PET/CT in patients with advanced NSCLC. British Journal of Cancer. ,vol. 110, pp. 363- 368 ,(2014) , 10.1038/BJC.2013.705