No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls

摘要: Individuals with alcohol-dependent parents show an elevated risk of developing alcohol-related problems themselves. Modulations the mesolimbic reward circuit have been postulated as a pre-existing marker alcoholism. We tested whether positive family history alcoholism is correlated ventral striatum functionality during task. All participants performed modified version monetary incentive delay task while their brain responses were measured functional magnetic resonance imaging. compared 206 healthy adolescents (aged 13-15) who had any first- or second-degree relative to matched controls no biological Reward anticipation well feedback win recruited in all participants, but did not differ from peers. Also we find correlation between density and win. This finding differences change when analyzed subsample 77 at least one parent alcohol use disorder controls. Because this result line another study reporting children young age, contrasts studies older individuals, might conclude that younger age effect has yet exerted its influence on still circuit.