Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers.

摘要: Aims Dysfunctional brain reward circuitry, particularly in the nucleus accumbens (NAcc), has been proposed as a risk factor for alcohol use disorder (AUD). This may be evident binge drinkers (BD), who are at high developing AUD. We examined whole-brain and NAcc reactivity to BD compared non-binge (NBD), hypothesizing that groups would differ their neural connectivity. Methods Healthy (N = 27) NBD 23)-none meeting AUD criteria-completed reward-guessing game, 'Doors' task, during functional magnetic resonance imaging. conducted an exploratory search group differences, but given our priori hypotheses, we also extracted activation from examine (Win > Loss) connectivity (FC) prefrontal cortex. Results Compared NBD, exhibited greater both right left relative loss. Additionally, positive FC between dorsal anterior cingulate (dACC) whereas showed negative these regions. Furthermore, less NAcc-dACC was related more past month use. Conclusions Our results provide preliminary evidence exhibit receipt is consistent with broader literature suggests aberrant precede onset. In addition, FC, perhaps reflecting deficient regulation of rewards losses. profile circuitry could represent correlates vulnerability Short summary drinkers, disorder, reduced cingulate, which associated