Striatal activation to monetary reward is associated with alcohol reward sensitivity.

摘要: One well-known phenotypic risk factor for the development of alcohol use disorder is sensitivity to rewarding effects alcohol. In present study, we examined whether individuals who are sensitive reward also nondrug rewards, thereby reflecting a broader individual difference factor. Specifically, tested hypothesis that subjective response acute would be related neural activation during monetary receipt relative loss (in absence alcohol). Community-recruited healthy young social drinkers (N = 58) completed four laboratory sessions in which they received (0.8 g/kg) and placebo alternating order under double-blind conditions, providing self-report measures at regular intervals. At separate visit 1–3 weeks later, reward-guessing game, ‘Doors’ task, fMRI drug-free state. Participants reported greater motivation (i.e., wanting) consume more after single moderate dose exhibited bilateral ventral caudate nucleus accumbens loss. Striatal was not other ratings including alcohol-induced sedation, stimulation, or pleasure feeling, liking). Our study first show indices humans. These results support growing evidence differences responses drug linked together form profile abuse, particularly adults.