Sphingolipids as differential regulators of cellular signalling processes
作者： S. Pyne , D. G. Tolan , A.-M. Conway , N. Pyne
DOI: 10.1042/BST0250549
关键词:
摘要: Sphingomyelin is a phospholipid that preferentially located in the outer leaflet of plasma membrane mammalian cells. It can be hydrolysed by three distinct isoforms phospholipase C (PLC)-like enzyme, sphingomyelinase, which are distinguished their pH optima and Mg2+-dependence. Activation sphingomyelinase occurs response to stimulation number cell-surface receptors variety biological agonists, such as cytokines growth factors [l]. Several metabolites sphingomyelin have been identified potential second-messenger molecules.
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