Preoperative immunostimulation by Propionibacterium granulosum KP-45 in colorectal cancer

摘要: In order to improve the perioperative resistance spread of cancer during operation effect preoperative stimulation immunesystem by Propionibacterium granulosum KP-45 was investigated in patients with colorectal carcinoma. a prospective randomized trial 101 were allocated either treatment (n = 51) or control 50). 10 mg Propioni bacteria administered intravenously between seventh and third day prior surgical treatment. At time 21 tumours classified as stage I (treatment n 12, 9), 22 II 10, 2). Postoperatively wound infections requiring more prevalent group 4) than treated 0). All subsequently followed up for 76 months. For carcinoma survival rates, excluding deaths, 91% 63% respectively. One case tumour metastasis seen group. rate 90% distant 1 45% where recurrence 55%. stages III IV there no statistically significant difference groups.