Adjuvant immunotherapy for solid tumors: From promise to clinical application

摘要: Although surgery remains the mainstay for treatment of most solid tumors, investigators are seeking complementary therapies to eradicate microscopic disease, which causes tumor relapse even after an apparently complete surgical excision. adjuvant chemotherapy has achieved some significant results, control minimal residual disease is still a challenge clinicians. Among novel therapeutic approaches, immunotherapy holds promise. This anticancer strategy aims at triggering highly specific endogenous killing machine against cells. Recent progress in immunology improved our understanding host-immune system interactions. In particular, new technologies have fostered identification potentially immunogenic antigens that can be used as suitable targets immune effector After observing immunotherapy-mediated clinical responses patients with metastatic started evaluating this modality setting. Here, we review immunological strategies so far explored humans and report worldwide results following application tumors.