Cardiorespiratory Anomalies in Mice Lacking CB1 Cannabinoid Receptors

摘要: Cannabinoid type 1 (CB1) receptors are expressed in the nervous and cardiovascular systems. In mice, CB1 receptor deficiency protects from metabolic consequences of a high-fat diet (HFD), increases sympathetic activity to brown fat, entails sleep anomalies. We investigated whether sleep-wake diet-dependent cardiorespiratory control is altered mice lacking receptors. knock-out (KO) intact wild-type (WT) were fed standard or HFD for 3 months, implanted with telemetric arterial pressure transducer electrodes scoring. Sleep state was assessed together heart rate (home cage), breathing (whole-body plethysmograph). Increases on passing light (rest) dark (activity) period KO significantly enhanced compared WT. These unaffected by cardiac (β1) vascular (α1) adrenergic blockade. The rhythm during also more irregular than that A increased rate, impaired vagal modulation, blunted central autonomic sleep. decreased baroreflex sensitivity but not conclusion, we performed first systematic study function deficient spontaneous wake-sleep behavior, demonstrated alters particularly presence HFD. signaling may thus play role physiological regulation protect some adverse