The implantable 5-fluorouracil-loaded poly(l-lactic acid) fibers prepared by wet-spinning from suspension
作者： Hao Gao , Yueqing Gu , Qineng Ping
DOI: 10.1016/J.JCONREL.2006.12.028
关键词:
摘要: Abstract The paper introduced an improved fabrication technique, by which the hydrophobic polymer monofilament fiber loading hydrophilic drug was obtained. micronized 5-Fu (5-fluorouracil) powders were homogeneously dispersed in PLLA (poly( l -lactic acid))–chloroform solution to form suspension, and then suspension solidified nonsolvent prepare fibers wet-spinning method under mild condition. diameter of drug-loaded range 50–250 μm. successfully encapsulated into with good stability, high content efficacy. MTT cytotoxicity assay vitro revealed satisfactory anticancer activity fibers. long-term release characteristics these also achieved. Furthermore, rate could be regulated formulation fabricating parameters, such as content, concentration composition flow wet-spinning. mechanism investigated described Fickian diffusion equation.
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