Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil
作者： Zhongshan Zhang , Quanbin Zhang , Jing Wang , Xuelian Shi , Jingjing Zhang
DOI: 10.1016/J.CARBPOL.2009.09.009
关键词:
摘要: Porphyran, the sulfated polysaccharide from red algae Porphyra haitanensis, possesses excellent bioactivities, especially the immune activity. In order to provide a water-soluble macromolecule prodrug of 5-FU showing slow release of 5-FU, reducing side-effect, we employed porphyran as a drug carrier, and carried out fixation of 5-FU to porphyran at 6-position through acetyl spacer group via ester bond. The chemical characteristic and release behavior of 5-FU from the conjugate obtained were studied in vitro at 37° C in three different …
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