The antitumor activity of a red alga polysaccharide complexes carrying 5-fluorouracil.
作者： Xiaomei Wang , Zhongshan Zhang
DOI: 10.1016/J.IJBIOMAC.2014.06.017
关键词: Immunocompetence 、 Porphyra haitanensis 、 Polysaccharide 、 Sulfation 、 Prodrug 、 Porphyran 、 Biology 、 Red algae 、 Galactan 、 Biochemistry
摘要: Porphyran is a sulfated galactan isolated from red algae Porphyra haitanensis, and have been reported to have many kinds of biological activities such as antitumor activity. In order to provide a water-soluble macromolecule prodrug of 5-Fu showing slow release of 5-Fu and reducing side-effect, we carried out fixation of 5-Fu to porphyran at 6-position. In this study, the antitumor and immunomodulation activities of low MW porphyran carrying 5-Fu on transplanted S180 tumor mice were studied. Weight of immune organ, proliferation ratio of …
sci-hub.se 参考文章(19)
G ZHOU, H XIN, W SHENG, Y SUN, Z LI, Z XU, In vivo growth-inhibition of S180 tumor by mixture of 5-Fu and low molecular λ-carrageenan from Chondrus ocellatus Pharmacological Research. ,vol. 51, pp. 153- 157 ,(2005) , 10.1016/J.PHRS.2004.07.003
Tatsuro Ouchi, Hajime Yuyama, Otto Vogl, Synthesis of poly(ethylene glycol)‐bound 3‐(5‐fluorouracil‐1‐yl)propanoic acid, its hydrolysis reactivity and antitumor activity Die Makromolekulare Chemie, Rapid Communications. ,vol. 6, pp. 815- 819 ,(1985) , 10.1002/MARC.1985.030061205
MICHAEL R. GRETZ, ESTHER L. MCCANDLESS, JEROME M. ARONSON, MILTON R. SOMMERFELD, The Galactan Sulphates of the Conchocelis Phases of Porphyra leucostricta and Bangia atropurpurea (Rhodophyta) Journal of Experimental Botany. ,vol. 34, pp. 705- 711 ,(1983) , 10.1093/JXB/34.6.705
Zhongshan Zhang, Quanbin Zhang, Jing Wang, Xuelian Shi, Jingjing Zhang, Houfang Song, Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil Carbohydrate Polymers. ,vol. 79, pp. 628- 632 ,(2010) , 10.1016/J.CARBPOL.2009.09.009
Ko Suzuki, Akio Tokoro, Yoshio Okawa, Shigeo Suzuki, Masuko Suzuki, Effect of N‐Acetylchito‐Oligosaccharides on Activation of Phagocytes Microbiology and Immunology. ,vol. 30, pp. 777- 787 ,(1986) , 10.1111/J.1348-0421.1986.TB03004.X
T. Ouchi, T. Banba, T. Matsumoto, S. Suzuki, M. Suzuki, Antitumor Activity of Chitosan and Chitin Immobilized 5-Fluorouracils through Hexamethylene Spacers via Carbamoyl Bonds: Journal of Bioactive and Compatible Polymers. ,vol. 4, pp. 362- 371 ,(1989) , 10.1177/088391158900400404
Zhongshan Zhang, Quanbin Zhang, Jing Wang, Hong Zhang, Xizhen Niu, Pengcheng Li, Preparation of the different derivatives of the low-molecular-weight porphyran from Porphyra haitanensis and their antioxidant activities in vitro. International Journal of Biological Macromolecules. ,vol. 45, pp. 22- 26 ,(2009) , 10.1016/J.IJBIOMAC.2009.03.009
Zhongshan Zhang, Quanbin Zhang, Jing Wang, Xuelian Shi, Houfang Song, Jingjing Zhang, In vitro antioxidant activities of acetylated, phosphorylated and benzoylated derivatives of porphyran extracted from Porphyra haitanensis Carbohydrate Polymers. ,vol. 78, pp. 449- 453 ,(2009) , 10.1016/J.CARBPOL.2009.04.026
Toshiki Sakamoto, Tsukasa Ezure, John Lunz, Noriko Murase, Hirokazu Tsuji, John J. Fung, Anthony J. Demetris, Concanavalin A simultaneously primes liver hematopoietic and epithelial progenitor cells for parallel expansion during liver regeneration after partial hepatectomy in mice Hepatology. ,vol. 32, pp. 256- 267 ,(2000) , 10.1053/JHEP.2000.9406
Tingting Zhao, Quanbin Zhang, Huimin Qi, Hong Zhang, Xizhen Niu, Zuhong Xu, Zhien Li, None, Degradation of porphyran from Porphyra haitanensis and the antioxidant activities of the degraded porphyrans with different molecular weight International Journal of Biological Macromolecules. ,vol. 38, pp. 45- 50 ,(2006) , 10.1016/J.IJBIOMAC.2005.12.018