Synthesis and Controlled Release of 5-Fluorouracil from Hydroxyethylchitosan: Based Polymer Prodrug
作者： Yanfei Peng , Wanshun Liu , Baoqin Han , Ruixue Zhou
DOI: 10.1007/978-3-642-37922-2_77
关键词:
摘要: A novel water-soluble hydroxyethylchitosan-based polymer prodrug of 5-fluorouracil ((HECS-5-Fu) was synthesized through acetyl spacer via ester bond. The conjugated content 5-Fu 12.2 % (w). In phosphate buffer solution (pH 7.4) at 37 °C, HECS-5-Fu slowly hydrolyzed to release 5-fluorouracil-1-yl-acetic acid as characterized by RP-HPLC and LC–MS. controlled drug from powder sustained for more than 25 days. in vitro experiment indicated that concentration 400 ug/mL inhibited the proliferation about 40.0 mouse fibroblast cell line L929. could have a potential application an antimetabolic material glaucoma filtration device implantation.
springer.com
sci-hub.st 参考文章(18)
Mitsuru Akashi, Kiichi Takemoto, New aspects of polymer drugs Springer, Berlin, Heidelberg. pp. 107- 146 ,(1990) , 10.1007/3-540-52834-2_4
Lisbeth Illum, Stanley S. Davis, Polymers in Controlled Drug Delivery ,(1988)
Kent L. Amsberry, A. Elise Gerstenberger, Ronald T. Borchardt, Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug. Pharmaceutical Research. ,vol. 8, pp. 455- 461 ,(1991) , 10.1023/A:1015890809507
Hans Bundgaard, The double prodrug concept and its applications Advanced Drug Delivery Reviews. ,vol. 3, pp. 39- 65 ,(1989) , 10.1016/0169-409X(89)90004-5
Marieta Nichifor, Etienne H Schacht, Leonard W Seymour, Polymeric prodrugs of 5-fluorouracil Journal of Controlled Release. ,vol. 48, pp. 165- 178 ,(1997) , 10.1016/S0168-3659(97)00048-5
Ye Liang, Wanshun Liu, Baoqin Han, Chaozhong Yang, Qun Ma, Weiwei Zhao, Mi Rong, Hui Li, Fabrication and characters of a corneal endothelial cells scaffold based on chitosan. Journal of Materials Science: Materials in Medicine. ,vol. 22, pp. 175- 183 ,(2011) , 10.1007/S10856-010-4190-6
Zhongshan Zhang, Quanbin Zhang, Jing Wang, Xuelian Shi, Jingjing Zhang, Houfang Song, Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil Carbohydrate Polymers. ,vol. 79, pp. 628- 632 ,(2010) , 10.1016/J.CARBPOL.2009.09.009
Koichi Udo, Kazuhiro Hokonohara, Keiichi Motoyama, Hidetoshi Arima, Fumitoshi Hirayama, Kaneto Uekama, 5-Fluorouracil acetic acid/β-cyclodextrin conjugates: Drug release behavior in enzymatic and rat cecal media International Journal of Pharmaceutics. ,vol. 388, pp. 95- 100 ,(2010) , 10.1016/J.IJPHARM.2009.12.039
M. Prabaharan, R.L. Reis, J.F. Mano, Carboxymethyl chitosan-graft-phosphatidylethanolamine: Amphiphilic matrices for controlled drug delivery Reactive & Functional Polymers. ,vol. 67, pp. 43- 52 ,(2007) , 10.1016/J.REACTFUNCTPOLYM.2006.09.001
Qing-Wei Wang, Xue-Ying Liu, Li Liu, Juan Feng, Yu-Hua Li, Zhen-Jun Guo, Qi-Bing Mei, Synthesis and evaluation of the 5-fluorouracil-pectin conjugate targeted at the colon Medicinal Chemistry Research. ,vol. 16, pp. 370- 379 ,(2007) , 10.1007/S00044-007-9049-0