Forskolin, adenylate cyclase, and cell physiology: an overview.

摘要: The potential of forskolin as a research tool is just beginning to be realized. Its use has revealed further subtleties the control cyclic AMP generation by adenylate cyclase in both solubilized and membrane preparations intact cells. It appears that an effect will become one criteria for implicating any physiological or biochemical response or, conversely, ruling out involvement AMP. Clinical applications hypotensive, spasmolytic, lipolytic, antithrombotic agents treatment glaucoma cardiac insufficiency remain other challenges future.