Laterality Preference and Cognition: Cross-Syndrome Comparison of Patients with Trisomy 21 (Down), del7q11.23 (Williams–Beuren) and del22q11.2 (DiGeorge or Velo-Cardio-Facial) Syndromes

摘要: We report on a cross-syndrome comparison of hand, foot, eye and ear laterality in three groups individuals with different genetic disorders (trisomy 21, del7q11.23, del22q11.2) to test the relationship between atypical intellectual disability. These were compared group typically developing persons. Hand, was assessed using item tasks, conducted twice, Bishop’s card-reaching test. Ordering mean IQ score for each as follows: trisomy 21 < del7q11.23 del22q11.2. observed same ordering IQ, particularly mixed handedness, degree laterality, hand foot consistency. The existence cognitive threshold, below which lateral preference is atypical, advocates causal link cognition those low although unknown other factors underlying both could determine this association.