Regulation of the rainbow trout (Oncorhynchus mykiss) hepatic β2-adrenoceptor by adrenergic agonists
作者： Stephen G. Dugan , Michel B. Lortie , James G. Nickerson , Thomas W. Moon
DOI: 10.1016/S1096-4959(03)00217-3
关键词:
摘要: The characteristics of hepatic beta(2)-adrenoceptors (AR) were examined in rainbow trout (Oncorhynchus mykiss) chased once per day to exhaustion for up 7 days or fed the repartitioning agents clenbuterol (CLEN) ractopamine (RACT) that function mammals as beta-agonists. A one-day chase and feeding CLEN 37 resulted a significant 27% 33% decrease, respectively, number CGP-binding sites (B(max)) with no change affinity (Kd) beta(2)-ARs. Despite decrease beta(2)-AR numbers feeding, differences found either mRNA levels adenylyl cyclase (ACase) activities. In addition, displayed only partial agonist activities it was be more effective at blocking isoproterenol-stimulated cAMP production isolated hepatocytes than stimulating production. small affects RACT may related its low active stereoisomer content beta(2)-AR. Agonist regulation beta(2)-ARs involve down-regulation receptors without affecting responsiveness.
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sci-hub.se 参考文章(38)
Lindsay Brown, Nicola M. Deighton, Susanne Bals, Werner Söhlmann, Hans-Reinhard Zerkowski, Martin C. Michel, Otto-Erich Brodde, Spare Receptors for β-Adrenoceptor-Mediated Positive Inotropic Effects of Catecholamines in the Human Heart Journal of Cardiovascular Pharmacology. ,vol. 19, pp. 222- 232 ,(1992) , 10.1097/00005344-199202000-00011
G. Brambilla, A. Bocca, M. Delise, E. Guandalini, Residues of clenbuterol in tissues of the rainbow trout (Oncorhynchus mykiss) Veterinary Research Communications. ,vol. 18, pp. 37- 42 ,(1994) , 10.1007/BF01839259
Michel Bouvier, William P. Hausdorff, Antonio De Blasi, Brian F. O'Dowd, Brian K. Kobilka, Marc G. Caron, Robert J. Lefkowitz, Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature. ,vol. 333, pp. 370- 373 ,(1988) , 10.1038/333370A0
Martin J. Lohse, Molecular mechanisms of membrane receptor desensitization Biochimica et Biophysica Acta. ,vol. 1179, pp. 171- 188 ,(1993) , 10.1016/0167-4889(93)90139-G
Steve G Reid, Marosh Furimsky, Steve F Perry, None, The effects of repeated physical stress or fasting on catccholamine storage and release in the rainbow trout, Oncorhynchus mykiss Journal of Fish Biology. ,vol. 45, pp. 365- 378 ,(1994) , 10.1111/J.1095-8649.1994.TB01319.X
E. Fabbri, A. Capuzzo, A. Gambarotta, T.W. Moon, Characterization of adrenergic receptors and related transduction pathways in the liver of the rainbow trout Comparative Biochemistry and Physiology B. ,vol. 112, pp. 643- 651 ,(1995) , 10.1016/0305-0491(95)00118-2
Peter J Munson, David Rodbard, None, Ligand: a versatile computerized approach for characterization of ligand-binding systems. Analytical Biochemistry. ,vol. 107, pp. 220- 239 ,(1980) , 10.1016/0003-2697(80)90515-1
M. Lohse, J. Benovic, J Codina, M. Caron, R. Lefkowitz, Beta-arrestin: a protein that regulates beta-adrenergic receptor function Science. ,vol. 248, pp. 1547- 1550 ,(1990) , 10.1126/SCIENCE.2163110
Elena Fabbri, Antonio Capuzzo, Thomas W Moon, THE ROLE OF CIRCULATING CATECHOLAMINES IN THE REGULATION OF FISH METABOLISM : AN OVERVIEW Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. ,vol. 120, pp. 177- 192 ,(1998) , 10.1016/S0742-8413(98)10017-8
J. Benovic, A DeBlasi, W. Stone, M. Caron, R. Lefkowitz, Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Science. ,vol. 246, pp. 235- 240 ,(1989) , 10.1126/SCIENCE.2552582