Accounting for a Quantitative Trait Locus for Plasma Triglyceride Levels: Utilization of Variants in Multiple Genes

作者: Lisa J. Martin , Ahmed H. Kissebah , Michael Olivier

DOI: 10.1371/JOURNAL.PONE.0034614

关键词:

摘要: Background For decades, research efforts have tried to uncover the underlying genetic basis of human susceptibility a variety diseases. Linkage studies resulted in highly replicated findings and helped identify quantitative trait loci (QTL) for many complex traits; however identification specific alleles accounting linkage remains elusive. The purpose this study was determine whether with sufficient number variants signal can be fully explained.

参考文章(48)
Dali Chen, Abhimanyu Garg, Monogenic disorders of obesity and body fat distribution Journal of Lipid Research. ,vol. 40, pp. 1735- 1746 ,(1999) , 10.1016/S0022-2275(20)34890-2
P. Watt, W. Wrieden, C. Bolton-Smith, C. N. A. Palmer, J. E. Cecil, B. Fischer, A. S. F. Doney, M. Hetherington, The Pro12Ala and C–681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren Diabetologia. ,vol. 48, pp. 1496- 1502 ,(2005) , 10.1007/S00125-005-1817-0
Xiao-Ying Dong, Sheng-Qiu Tang, Insulin-induced gene: a new regulator in lipid metabolism. Peptides. ,vol. 31, pp. 2145- 2150 ,(2010) , 10.1016/J.PEPTIDES.2010.07.020
Georg B Ehret, Ashley A O'Connor, Alan Weder, Richard S Cooper, Aravinda Chakravarti, Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study European Journal of Human Genetics. ,vol. 17, pp. 1650- 1657 ,(2009) , 10.1038/EJHG.2009.94
Ruzong Fan, Momiao Xiong, Combined high resolution linkage and association mapping of quantitative trait loci. European Journal of Human Genetics. ,vol. 11, pp. 125- 137 ,(2003) , 10.1038/SJ.EJHG.5200941
Philippe Debeer, Valerie Race, Marc Gewillig, Koen Devriendt, Jean-Pierre Frijns, Novel TBX5 mutations in patients with Holt-Oram syndrome. Clinical Orthopaedics and Related Research. ,vol. 462, pp. 20- 26 ,(2007) , 10.1097/BLO.0B013E3181123FFE
Young-Wook Cho, SunHwa Hong, Qihuang Jin, Lifeng Wang, Ji-Eun Lee, Oksana Gavrilova, Kai Ge, Histone Methylation Regulator PTIP Is Required for PPARγ and C/EBPα Expression and Adipogenesis Cell Metabolism. ,vol. 10, pp. 27- 39 ,(2009) , 10.1016/J.CMET.2009.05.010
Albert M. Levin, Mitchell J. Machiela, Kimberly A. Zuhlke, Anna M. Ray, Kathleen A. Cooney, Julie A. Douglas, Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. Cancer Research. ,vol. 68, pp. 6492- 6495 ,(2008) , 10.1158/0008-5472.CAN-08-0348
Sophie M. Banas, Claude Rouch, Nadim Kassis, Eirini M. Markaki, Kyriaki Gerozissis, A Dietary Fat Excess Alters Metabolic and Neuroendocrine Responses Before the Onset of Metabolic Diseases Cellular and Molecular Neurobiology. ,vol. 29, pp. 157- 168 ,(2009) , 10.1007/S10571-008-9307-9
Shane McCarthy, Salim Mottagui-Tabar, Yumi Mizuno, Bengt Sennblad, Johan Hoffstedt, Peter Arner, Claes Wahlestedt, Björn Andersson, Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin. Human Genetics. ,vol. 117, pp. 545- 557 ,(2005) , 10.1007/S00439-005-1328-6