History of Antibiotics. From Salvarsan to Cephalosporins

作者: Lorenzo Zaffiri , Jared Gardner , Luis H. Toledo-Pereyra

DOI: 10.3109/08941939.2012.664099

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摘要: ABSTRACTInfections have represented for a long time the leading cause of death in humans. During 19th century, pneumonia, tuberculosis, diarrhea and diphtheria were considered main causes children adults. Only late century did it become possible to correlate existence microscopic pathogens with development various diseases. Within few years introduction antiseptic procedures had begun reduce mortality due postsurgical infections. Sanitation hygiene played significant role reduction several infectious The first compounds antimicrobial activity succeeded conquering many diseases.In this review we analyzed, from historical perspective, antibiotics circumstances that led their discovery. compound was introduced 1911 by Erlich. He focused his research on discovery “magic bullet” t...

参考文章(154)
Laura L George, Thomas J Borody, Peter Andrews, Michele Devine, Deborah Moore‐Jones, Mary Walton, Susan Brandi, Cure of duodenal ulcer after eradication of Helicobacter pylori. The Medical Journal of Australia. ,vol. 153, pp. 145- 149 ,(1990) , 10.5694/J.1326-5377.1990.TB136833.X
H. S. Burton, E. P. Abraham, Isolation of antibiotics from a species of Cephalosporium; cephalosporins P1, P2, P3, P4, and P5. Biochemical Journal. ,vol. 50, pp. 168- 174 ,(1951) , 10.1042/BJ0500168
J. H. Jr. Comroe, Pay dirt: the story of streptomycin. Part I. From Waksman to Waksman. The American review of respiratory disease. ,vol. 117, pp. 773- 781 ,(1978) , 10.1164/ARRD.1978.117.4.773
Abraham Ep, Chain E, An enzyme from bacteria able to destroy penicillin. 1940. Clinical Infectious Diseases. ,vol. 10, pp. 677- ,(1988)
Jackson Jm, Pelle M, Topical rosacea therapy: the importance of vehicles for efficacy, tolerability and compliance. Journal of Drugs in Dermatology. ,vol. 10, pp. 627- ,(2011)
R Tompsett, Enterococcal endocarditis: duration and mode of treatment. Transactions of the American Clinical and Climatological Association. ,vol. 89, pp. 49- 57 ,(1978)
Bronwen Loder, G. G. F. Newton, E P Abraham, The cephalosporin C nucleus (7-aminocephalosporanic acid) and some of its derivatives Biochemical Journal. ,vol. 79, pp. 408- 416 ,(1961) , 10.1042/BJ0790408
Pfuetze Kh, Feldman Wh, Hinshaw Hc, Pyle Mm, The first clinical trial of streptomycin in human tuberculosis. American review of tuberculosis. ,vol. 71, pp. 752- ,(1955) , 10.1164/ARTPD.1955.71.5.752
Dorothy G. Smith, Selman A. Waksman, Tuberculostatic and Tuberculocidal Properties of Streptomycin 12 Journal of Bacteriology. ,vol. 54, pp. 253- 261 ,(1947) , 10.1128/JB.54.2.253-261.1947
Jennings Ma, Gardner Ad, Fletcher Cm, Florey Hw, Abraham Ep, Chain E, Heatley Ng, Further observations on penicillin. 1941. European Journal of Clinical Pharmacology. ,vol. 42, pp. 3- 9 ,(1992)