Topical rosacea therapy: the importance of vehicles for efficacy, tolerability and compliance.

摘要: Many topical medications are available for the treatment of papulopustular rosacea. While treatments contain metronidazole, azelaic acid, or sodium sulfacetamide-sulfur as active ingredient, composition vehicle formulations varies widely. These vehicles come in gels, creams, lotions and foams; some ingredients common to many vehicles, while unique designed optimize skin penetration delivery drug its target. Vehicles can also influence tolerability, which is always a concern patients with heightened sensitivity, compliance, typically lower than oral treatments. Ideally, any rosacea should enhance delivery, be nonirritating easy use. Ingredients that help repair barrier function desirable. This review will focus on key components from most commonly used therapies how repair, tolerability compliance.