The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes.

摘要: Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. We studied the role played by total adiponectin bioactive high-molecular-weight (HMW) oligomeric complexes of in vascular function offspring whose parents both had type 2 diabetes, a population at high risk diabetes atherosclerosis. Total %HMW adiponectin, cytokines C-reactive protein, interleukin-6 plasminogen activator inhibitor-1 (PAI-1), as well lipid profiles were assayed 19 offspring, each two diabetic parents. Subjects underwent OGTTs IVGTTs. Endothelium-dependent vasodilation (EDV) was assessed brachial artery ultrasonography. There significant relationship between levels (r=0.72, p=0.001). Despite expected strong positive correlation HDL-cholesterol (r=0.52, p=0.04), EDV (r=0.56, p<0.02), there no either or % HMW EDV. inversely associated PAI-1 (r=0.50, p=0.05), but did not correlate inflammatory markers protein interleukin-6. In parents, atherosclerotic disease, endothelium-dependent vasodilation. However, low impaired fibrinolysis manifested increased inhibitor-1.