Prognostic Impact of Malignant Pleural Effusion at Presentation in Patients with Metastatic Non–Small-Cell Lung Cancer

摘要: Background Despite its common occurrence, the influence of malignant pleural effusion (MPE) on outcomes patients with advanced non–small-cell lung cancer (NSCLC) distant metastasis (M1b) is unknown. We evaluated clinical characteristics associated MPE at presentation and prognostic impact in stage M1b NSCLC. Methods extracted data from Surveillance Epidemiology End Results (SEER) registry NSCLC diagnosed between 2004 2005. Odds-ratio estimates were calculated using logistic regression, Kaplan–Meier method was used to estimate overall survival. Cox proportional hazard model evaluate whether an independent risk for outcome. Among 57,685 patients, present 9170 (15.9%), including 3944 out 31,506 (12.5%) without metastases 5226 (20.0%) 26,179 M1b. The probability higher larger tumors, mediastinal lymph node involvement, adenocarcinoma, not otherwise specified, or large-cell histology. In M1b, median survival (3 months versus 5 months), estimated 1-year (12.6% 24.8%), 2-year (5.4% 11.3%) significantly lower compared those (hazards ratio 1.49, 95% confidence interval 1.44–1.54, p Conclusions a complication decreased metastases. If these are validated, subsequent studies may consider stratification according status.