One‐hour post‐load plasma glucose and IGF‐1 in hypertensive patients

摘要: Eur J Clin Invest 2012; 42 (12): 1325–1331 Abstract Background  In normoglucose-tolerant subjects (NGT), 1-h post-load plasma glucose value ≥155 mg/dL, during an oral tolerance test (OGTT), is associated with increased risk of type-2 diabetes (T2D) and subclinical organ damage. Insulin-like growth factor-1 (IGF-1) involved in the pathogenesis insulin resistance (IR) T2D. Moreover, hypertensives have different degrees IR levels IGF-1. Actually, there are no data supporting association between IGF-1; thus, aim study was to investigate this relationship. Materials methods  We enrolled 1126 never-treated hypertensive who underwent OGTT clinical characterization. Insulin sensitivity assessed by Matsuda index. IGF-1 measured a sensitive immunoradiometric assay. Results  Among participants, 764 had NGT, 263 impaired (IGT) 99 According cut-off point 155 mg/dL, we divided NGT into NGT < 155 mg/dL NGT ≥ 155 mg/dL. NGT ≥ 155 comparison NGT < 155 significantly reduced levels. At multiple regression analysis, major determinant subjects, IGT diabetics, accounting for 20·9%, 17·7% 15·5% its variation respective models. Conclusions  results strongly glucose, similarly that observed diabetics. This finding has relevance because both low damage, independent predictor cardiovascular events.