Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients.
作者： Giorgio Sesti , Angela Sciacqua , Angela Scozzafava , Marco Vatrano , Elvira Angotti
DOI: 10.1097/HJH.0B013E3280112B63
关键词:
摘要: OBJECTIVES: Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) interfere with cardiac mass (left ventricular mass; LVM) development. We investigated the role of GH/IGF-1 axis on LVM geometry in a group 230 never-treated hypertensive patients. METHODS: Partition values for left hypertrophy (LVH) were 125 g/m2 both women men. Insulin resistance was estimated by homeostasis model assessment (HOMA) index. RESULTS: A significant inverse correlation observed between IGF-1 fasting insulin (r = -0.249; P < 0.0001) GH -0.218; 0.0001). Systolic blood pressure (157.3 +/- 13.6 versus 149.4 12.8 mmHg; 0.001), (17.4 8.5 11.4 6.0 microU/l; 0.0001), HOMA (4.4 2.3 2.9 1.6; (1.0 1.0 0.4 0.5 ng/ml; significantly higher patients LVH; contrary, (119.1 47.8 160.1 75.5 without LVH. In logistic regression analysis, strongest independent predictors LVH [relative risk (RR) 2.078; 95% confidence interval (CI) 1.364-3.163], (RR 1.345; CI 1.133-1.596), 0.993; 0.998-0.999) systolic 1.036; 1.013-1.060). showed an opposite trend eccentric concentric hypertrophy. CONCLUSIONS: Present data demonstrate that increase prevalent human essential hypertension is directly associated serum levels inversely related to circulating IGF-1.
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