Creatinine and insulin predict cardiac mass in drug-naïve hypertensive patients.

摘要: Abstract Background Blood pressure (BP) affects hypertensive left ventricular mass (LVM), explaining 10–25% of its variation. Thus, it is plausible that other factors operate in this process. Reduced kidney function associated with increased LVM. Methods We enrolled 1000 untreated hypertensives serum creatinine ≤1.5mg/dL and without proteinuria. BP was measured by standard sphygmomanometer. LVM calculated the Devereux formula indexed body surface area (LVMI). Anthropometric following laboratory parameters were measured: plasma glucose, insulin, cholesterol, triglyceride, e-GFR (CKD-EPI equation). Results On univariate analysis, both insulin (r=0.44, P 2 LVMI patients higher (upper quartiles). Conclusions Independently risk factors, fasting contribute to explain development preserved renal function; interacts variability these patients.