External validation of the pretreatment nomogram to predict acute urinary retention after 125I prostate brachytherapy
作者： Ellen M. Roeloffzen , Juanita Crook , Evelyn M. Monninkhof , Michael McLean , Marco van Vulpen
DOI: 10.1016/J.BRACHY.2011.12.011
关键词:
摘要: Abstract Purpose Acute urinary retention (AUR) after 125 I prostate brachytherapy has a negative impact on quality of life. Recently, the authors developed nomogram to predict risk AUR preoperatively. The aim this study was assess external validity nomogram. Methods and Materials initially 714 patients treated with at University Medical Center Utrecht, Netherlands. Predictive factors included in were volume, international symptom score, neoadjuvant hormonal treatment, protrusion. For validation, data 715 consecutive between January 2003 July 2008 Princess Margaret Hospital, Toronto, used. performance evaluated by discrimination (ability distinguish who develop yes or no) calibration (agreement observed predicted numbers AUR). Results Of 67 (9.4%) compared 8.0% Utrecht cohort. In validation set, discriminatory ability good (receive operating characteristic area: 0.86; 95% confidence interval: 0.82–0.91), comparable derivation set 0.82; 0.77–0.88). Comparison risks frequencies showed underestimation for high values. Still, predictive value AUR, using cutoff 5%, (98.1%). Conclusion External shows adequate without AUR. Therefore, can aid individualized treatment decision making.
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