A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.

摘要: Viral and host factors influence the rate of HIV-1 disease progression. For to fuse, a CD4+ cell must express co-receptor that virus can use. The chemokine receptors CCR5 CXCR4 are used by R5 X4 viruses, respectively. Most new infections involve transmission but variants arise later also use (R5-X4 or viruses). This is associated with an increased T-cell loss poor prognosis. ability cells support entry influences absence in approximately 1% Caucasian population, due homozygosity for 32-nucleotide deletion coding region (delta32-CCR5 allele), very strongly protects against transmission. Heterozygosity delta32-CCR5 allele delays progression typically 2 years. A recent study showed conservative substitution (V64I) CCR2 has significant impact on progression, not was unexpected, since rarely as vitro V64I change transmembrane region. Because subsequent did confirm this effect disease, we analyzed CCR2-V64I using subjects Chicago MACS. We show indeed protective go complete linkage disequilibrium point mutation regulatory