The impact of human genetic variation on HIV disease in the era of HAART.

摘要: Human genetic variation may directly or indirectly influence response to modern antiretroviral therapies for HIV. It is already known that some immunogenetic and other human variations affect the natural history of HIV disease progression where individuals are untreated, but less information available as whether these differences still relevant in context HAART. Antiretroviral therapy adds additional opportunities contributions variable prognosis--in particular those genes which pharmacokinetics and/or adverse events. To date, majority studies investigating on treatment outcome have focused single nucleotide polymorphisms a small number within gene. Reports date generally described effect sizes, often been contradictory. Thus, while simple markers indeed identified (e.g. CCR5delta32 untreated disease, HLA-B*5701 allele abacavir hypersensitivity reaction HAART), it more likely outcomes influenced by multitude interacting genotypes phenotypes, hypothesis will become increasingly possible investigate improvements molecular computational technologies made.