Host determinants in HIV infection and disease. Part 1: cellular and humoral immune responses.

摘要: The course of HIV infection varies widely among individuals. Long-term nonprogressors or slow progressors may remain asymptomatic and have normal CD4 counts despite more than a decade untreated infection. In contrast, rapid develop AIDS within 5 years. addition, some persons uninfected repeated exposure to HIV. Immunologic genetic studies long-term exposed yet persons, as well data from primary infection, helped elucidate the mechanisms by which are protected acquisition rates disease progression. This review (the first two parts) describes what is currently known about host factors in HIV-1 Studies for inclusion were identified systematic search PubMed English-language literature published 1988 through June 2000. Abstracts presentations at major meetings convened 2000 also included if appropriate. Growing evidence suggests crucial role cytotoxic T cells T-helper controlling viremia, slowing progression, perhaps preventing establishment Humoral mucosal immunity, soluble inhibitory factors, cytokine milieu, concomitant infections affect outcome. Genetic such inheritance mutant chemokine receptors certain HLA types, susceptibility subsequent clinical course. cellular humoral other local determining discussed.