Familial occurrence of oral submucous fibrosis: report of eight families from northern Kerala, south India.

摘要: BACKGROUND Oral submucous fibrosis (OSF) is an archetype of pathological due to possibly its presence for centuries amongst people Indian ethnic extraction. The WHO criteria a precancerous condition accords well with this disease. fact that the disease has been reported in at least few subjects who do not practice habit areca nut chewing and inability prove dose-effect relationship almost all cases, question arose whether there predisposition METHODS A house- to-house survey was carried out northern Kerala, South India, detection early advanced OSF from June 2003 through May 2004. An analysis family pedigrees patients positive history out. RESULTS Preliminary revealed tends aggregate families. eight (8) such families presented here concept having genetic occurrence revisited. CONCLUSION view predilection, proportion tendency familial linkage seems be apparent by study. This rather denovo observation trend between risk number putative high-risk genotypes should separately evaluated collagen metabolizing cross-linking pathways. Establishing initial step deciphering further molecular pathways involved causation biologic progression.