Molecular pathways regulated by areca nut in the etiopathogenesis of oral submucous fibrosis

摘要: Many oral mucosal lesions are due to substance abuse, such as tobacco and areca nut, amongst others. There is considerable evidence that lesions/disorders some leukoplakias, most erythroplakias, submucous fibrosis have malignant potential, with a conversion rate of 5%-10% over 10-year period. been several reports on possible biomarkers predict the associated these disorders. Management mostly surgical removal lesion followed by observation, in cases treatment antioxidants anti-inflammatory agents. Oral excessive deposition extracellular matrix connective tissue plus, particularly, collagens. The collagen leads stiffness affected regions results difficulty mouth opening. Areca nut chewing proposed probable etiological factor manifestation fibrosis. Several studies suggest involvement proinflammatory cytokines, dysregulated development disease. Amongst these, transforming growth factor-β forefront, which also shown be involved other organs. This review addresses molecular mechanisms provides model for regulation nut. It an exemplar role modern techniques study