MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases
作者： Xiao-Zhou Zou , Ting Liu , Zhi-Cheng Gong , Chang-Ping Hu , Zheng Zhang
DOI: 10.1016/J.EJPHAR.2016.12.003
关键词: microRNA 、 Cancer research 、 Pulmonary fibrosis 、 Signal transduction 、 Renal fibrosis 、 Epithelial–mesenchymal transition 、 Fibrosis 、 Immunology 、 Hepatic fibrosis 、 Biology 、 Cardiac fibrosis
摘要: MicroRNAs (miRNAs), a large family of small and highly conserved non-coding RNAs, regulate gene expression through translational repression or mRNA degradation. Aberrant miRNAs underlies spectrum diseases including organ fibrosis. Recent evidence suggests that contribute to fibrosis mediating epithelial-mesenchymal transition (EMT). Alleviation EMT has been proposed as promising strategy against fibrotic given the key role in impact specific ligands, receptors, signaling pathways, thus modulating consequently influencing This review summarizes current knowledge concerning how highlights roles miRNAs-regulated plays diverse pulmonary fibrosis, hepatic renal cardiac It is desirable more comprehensive understanding functions will facilitate development novel diagnostic therapeutic strategies for various debilitating
elsevier.com
sci-hub.se 参考文章(225)
Ping Liu, Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B World Journal of Gastroenterology. ,vol. 8, pp. 679- 685 ,(2002) , 10.3748/WJG.V8.I4.679
Raphael Kopan, Notch: a membrane-bound transcription factor. Journal of Cell Science. ,vol. 115, pp. 1095- 1097 ,(2002) , 10.1242/JCS.115.6.1095
Manfred Kunz, MicroRNAs in Melanoma Biology Advances in Experimental Medicine and Biology. ,vol. 774, pp. 103- 120 ,(2013) , 10.1007/978-94-007-5590-1_6
Jianbo Yue, Kathleen M. Mulder, Activation of the mitogen-activated protein kinase pathway by transforming growth factor-beta. Methods of Molecular Biology. ,vol. 142, pp. 125- 131 ,(2000) , 10.1385/1-59259-053-5:125
Li Xiao, Xun Zhou, Fuyou Liu, Chun Hu, Xuejing Zhu, Ying Luo, Ming Wang, Xiaoxuan Xu, Shikun Yang, Yashpal S Kanwar, Lin Sun, MicroRNA-129-5p modulates epithelial-to-mesenchymal transition by targeting SIP1 and SOX4 during peritoneal dialysis Laboratory Investigation. ,vol. 95, pp. 817- 832 ,(2015) , 10.1038/LABINVEST.2015.57
Chen Liang, Zhen Wang, Ying-Yi Li, Bao-Hua Yu, Fei Zhang, Hong-Yu Li, miR-33a suppresses the nuclear translocation of β-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells. Tumor Biology. ,vol. 36, pp. 9395- 9403 ,(2015) , 10.1007/S13277-015-3679-5
Jussi Taipale, Philip A. Beachy, The Hedgehog and Wnt signalling pathways in cancer Nature. ,vol. 411, pp. 349- 354 ,(2001) , 10.1038/35077219
Maoyun Wang, Yuchuan Huang, Zong'an Liang, Dan Liu, Yanrong Lu, Ya Dai, Guanglin Feng, Changguo Wang, Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease Clinical Respiratory Journal. ,vol. 10, pp. 104- 111 ,(2016) , 10.1111/CRJ.12194
Zhengping Zhang, Zhongfei Gao, Wei Hu, Shan Yin, Chunming Wang, Yuhui Zang, Jiangning Chen, Junfeng Zhang, Lei Dong, None, 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. British Journal of Pharmacology. ,vol. 170, pp. 649- 660 ,(2013) , 10.1111/BPH.12323
Joan Massagué, How cells read TGF-beta signals. Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 169- 178 ,(2000) , 10.1038/35043051