摘要: The MAPKs are one of Nature's preferred "solutions" for signaling, and the basic three-kinase module has been replicated various tasks in all eukaryotes. While overall structure is remarkably conserved, inputs outputs diverse unpredictable. Although did not turn out to be "missing link" between tyrosine serine/threonine kinases, their importance transcends such a simple bridge acting as adaptable conduits environment appropriate cellular response. As already demonstrated p38 MAPK, pharmaceutical modulation pathways may have therapeutic benefit. Indeed, MEK Raf inhibitors undergoing clinical trials treatment certain cancers. more selective, small-molecule developed, additional indications inflammation, arthritis, autoimmunity benefit from MAPK medicinal chemistry.
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