Glycosylation of the variant surface antigens of Trypanosoma brucei.
作者： A. A. Holder
DOI: 10.1007/978-3-642-70538-0_3
关键词:
摘要: The variant-specific protein that forms the surface coat of bloodstage trypanosome Trypanosoma brucei is a glycoprotein, with oligosaccharides attached by covalent linkage to specific residues in protein. organism able express sequentially individual genes from large repertoire antigen and glycosylation each these gene products has been shown binding lectins (Strickler et al. 1978), direct detection sugars associated (Allsopp Njogu 1974; Johnson Cross 1977) or effects various inhibitors on biosynthesis Patton 1980; Rovis Dube 1981). proteins related trypanosomes T. congolense (Rautenberg 1981; Reinwald 1981) equiperdum (Baltz are also glycosylated. molecular basis antigenic variation biochemistry variant glycoproteins (VSGs) have reviewed recently (Turner 1982; Borst Englund 1982). This chapter will describe what known about location, biosynthesis, processing structure carbohydrate VSGs assess their possible significance for biology parasite.
springer.com
sci-hub.st 参考文章(56)
T. Baltz, C. Giroud, D. Baltz, G. Duvillier, P. Degand, J. Demaille, R. Pautrizel, The variable surface glycoproteins of Trypanosoma equiperdum are phosphorylated. The EMBO Journal. ,vol. 1, pp. 1393- 1398 ,(1982) , 10.1002/J.1460-2075.1982.TB01328.X
A F Barbet, G Mpimbaza, A J Musoke, T Vervoort, E Magnus, N Van Meirvenne, Isotypic surface glycoproteins of trypanosomes. Immunology. ,vol. 44, pp. 223- ,(1981)
G. Duvillier, A. Nouvelot, C. Richet, T. Baltz, P. Degand, Presence of glycerol and fatty acids in the C-terminal end of a variant surface glycoprotein from Trypanosoma equiperdum Biochemical and Biophysical Research Communications. ,vol. 114, pp. 119- 125 ,(1983) , 10.1016/0006-291X(83)91602-9
M.C. Labastie, T. Baltz, C. Richet, Ch. Giroud, G. Duvillier, R. Pautrizel, P. Degand, Variant specific glycoproteins of Trypanosoma equiperdum: cross reacting determinants and chemical studies. Biochemical and Biophysical Research Communications. ,vol. 99, pp. 729- 736 ,(1981) , 10.1016/0006-291X(81)91804-0
A. A. Holder, J. C. Boothroyd, G. A. M. Cross, Trypanosome variant surface glycoprotein: the C-terminus of the protein is the location of antigenically cross reacting carbohydrate groups, of a putative membrane attachment sequence and the site of proteolytic processing. Trypanosome variant surface glycoprotein: the C-terminus of the protein is the location of antigenically cross reacting carbohydrate groups, of a putative membrane attachment sequence and the site of proteolytic processing.. pp. 249- 252 ,(1980)
A J Parodi, J J Cazzulo, Protein glycosylation in Trypanosoma cruzi. II. Partial characterization of protein-bound oligosaccharides labeled "in vivo". Journal of Biological Chemistry. ,vol. 257, pp. 7641- 7645 ,(1982) , 10.1016/S0021-9258(18)34428-4
Christopher T. BRETT, H. Paul VOORHEIS, Glycoprotein Biosynthesis in Trypanosoma brucei FEBS Journal. ,vol. 109, pp. 139- 150 ,(1980) , 10.1111/J.1432-1033.1980.TB04778.X
A J Parodi, L A Quesada-Allue, Protein glycosylation in Trypanosoma cruzi. I. Characterization of dolichol-bound monosaccharides and oligosaccharides synthesized "in vivo". Journal of Biological Chemistry. ,vol. 257, pp. 7637- 7640 ,(1982) , 10.1016/S0021-9258(18)34427-2
F. Michiels, G. Matthyssens, P. Kronenberger, E. Pays, B. Dero, S. Van Assel, M. Darville, A. Carvador, M. Steinert, R. Hamers, Gene activation and re-expression of a Trypanosoma brucei variant surface glycoprotein. The EMBO Journal. ,vol. 2, pp. 1185- 1192 ,(1983) , 10.1002/J.1460-2075.1983.TB01565.X
Alvin Y.C. Liu, Lex H.T. Van der Ploeg, Frans A.M. Rijsewijk, Piet Borst, P. Chambon, The transposition unit of variant surface glycoprotein gene 118 of Trypanosoma brucei: Presence of repeated elements at its border and absence of promoter-associated sequences Journal of Molecular Biology. ,vol. 167, pp. 57- 75 ,(1983) , 10.1016/S0022-2836(83)80034-5