Anaerobic threshold: review of the concept and directions for future research

摘要: The concentration of lactate in the blood is result (1) those processes which produce and contribute to its appearance (2) catabolize after removal from blood. Consequently, provides minimal information about rate production muscle. accumulation beyond threshold [T(lact)] does provide an indication that mechanisms fail keep pace with production. Lactate produced skeletal muscle as a direct increased metabolic glycolytic carbon flow. Factors influence include: Vmax lactic dehydrogenase (LDH), several times greater than combined activities enzymes alternative pathways pyruvate metabolism; kM LDH for pyruvate, sufficiently low assure maximal stimulation conversion lactate; K'eq conversion, exceeds 1000. Recent studies on dog gracilis situ clearly indicate occurs contracting pure red reasons other O2 limitation mitochondrial ATP In addition failure essential assumption anaerobic [T(an)] hypothesis there exist limitations availability muscles healthy individuals during submaximal exercise, groups investigators have results parameters associated changes pulmonary minute ventilation [i.e., ventilatory threshold, T(vent)] do not always track concentration. Therefore, T(an) fails bases theory prediction. A series kinetic tracer experiments better understand kinetics exercise proposed.