Properties of a toxin from the salivary gland of the shrew, Blarina brevicauda.

摘要: The toxin found in the submaxillary gland of shrew, Blarina brevicauda, has been stabilized by drying fresh with acetone. was concentrated about four times precipitation ammonium sulfate ("purified toxin"). LD 50 purified mice is 3.4 mgm./kgm. Cats were killed similar doses, while rabbits much more susceptible to toxin. appeared be protein nature since it precipitated sulfate, non-dialyzable, and inactivated trypsin pepsin. In anesthetized cats, vascular effects responsible for lethal action. Atropine amid artificial respiration did not protect animals. Peripheral vasodilatation probably accounted primary fall blood pressure. Stimulatiomi suprarenal medullary secretion demonstrated release sympathin may account secondary hypertension tachycardia. isolated atropinized guinea pig ileum virgin uterus stimulated contraction histamine-like character on vascular, intestinal uterine muscles discussed.