Integrin-Activated Reactions to Metallic Implant Surfaces

摘要: With the current increase in demand for implants younger patients, rapidly aging populations, and patients with tissue impairment due to disease, there is a need improve functional integration life span of at cellular level, order be able substitute or augment complex tissues organs. In many cases, stimulation ingrowth specific, native, seeded cells form continuum biomaterial required. One major pathways by which adhere interact their extracellular environment through integrins, activate intracellular-signaling that are essential cell survival, growth, differentiation. Therefore, understanding role integrins cell/tissue response biomaterials success implants. Discussed this article brief overview functions, signaling pathways, having integrin-activating surfaces, particular attention bone metal Generating peptides and/or proteins has resulted some as significant increases early formation have been obtained, both vitro vivo. However, our ultimate goal provide long lasting implant still needs realized respect