Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia.

摘要: Abstract Catechol-O-methyltransferase (COMT) gene variants have been reported to be implicated in the pathogenesis of psychotic symptoms schizophrenia , especially negative symptoms. These including apathy, blunted affect social withdrawal and motor retardation. Neuroimaging studies suggested that appear associated with impaired activities prefrontal cortex particular dorsolateral (DLPFC). Given COMT is highly expressed DLPFC, it poorly understood whether disease state val 158met polymorphisms main interactive effect on resting functional connectivity (RSFC) DLPFC-related pathways. To this end, fifty-five first episode (FES) fifty-three healthy controls were genotyped using blood samples underwent magnetic resonance imaging scanning. Seed-based voxel wise analysis was performed by placing bilateral pairs seeds DLPFC area 46 defined Brodmann's atlas. A two-ways ANCOVA model val158 met genotypes as between subjects factors. Significant disease × COMT found mainly left anterior cingulate cortex, right precuneus superior parietal gyrus which overlapped effect. And these RSFC had positive correlations affective blunting scores FES patients homozygotes, but not carriers. Our results showed significant provided evidence for a disease-dependent pattern action.