Temperament and character in remitted and symptomatic patients with schizophrenia: Modulation by the COMT Val158Met genotype

摘要: While research on remission in schizophrenia has gained attention, personality characteristics associated with have been under-studied. A functional valine-to-methionine (Val158Met) polymorphism the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of despite weak or no association disorder itself. Studies also report that this can affect traits. We aimed examine traits remitted patients as compared symptomatic and healthy controls investigate whether COMT Val158Met influences their personality. Scores Temperament Character Inventory were between 34 outpatients schizophrenia, age- sex-matched 72 matched 247 individuals. The effect was examined each group. analysis covariance, controlling for confounding variables, revealed controls, exhibited a pervasively altered profile whereas showed alterations more limited dimensions demonstrated normal levels novelty-seeking, reward dependence cooperativeness. two-way genotype sex between-subject factors confounders covariates, Met carriers significantly lower cooperativeness than Val homozygotes patients; while significant found These findings indicate relatively adaptive patients. might modulating relationship remission.