Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress

摘要: Peerbooms O, Rutten BPF, Collip D, Lardinois M, Lataster T, Thewissen V, Mafi Rad S, Drukker Kenis G, van Os J, Myin-Germeys I, Winkel R. Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress. Objective:  A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met methylenetetrahydrofolate reductase (MTHFR) C677T has been shown differentially affect cognition in patients with schizophrenia healthy controls; the effect Val158Met × MTHFR on resilience stress controls remains be examined. Method:  total 98 non-affective disorder 118 were genotyped for C677T, A1298C, COMTVal158Met. Daily life reactivity stress, modelled as daily experiences, was measured using experience sampling method (ESM). Results:  The genotype moderated (P < 0.0001), but not (P = 0.68). Further examination this revealed 677 T-allele, Met/Met individuals displayed largest increases symptoms reaction ESM [χ2(2) = 29.51; P < 0.0001], whereas C/C no significant Val158Met × ESM apparent [χ2(2) = 3.65; P = 0.16]. No moderating A1298C found. Conclusion:  Stress associated psychosis may crucially depend genotype.